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They work intracellularly to block the JAK/STAT signaling pathway, effectively intercepting the downstream signaling of multiple pro-inflammatory cytokines that drive RA tofacitinib mono-therapy has been found to be superior to methotrexate in reducing the symptoms and progression of RA

Innate Immun (2021) 27:3140

Genetic commonalities between metabolic syndrome and rheumatic diseases through disease interactome modules

Common Dietary Changes That May Trigger Loose Stools When people enter a calorie deficit, they often make several simultaneous dietary changes, any one of which could independently affect bowel habits

PMID 16783540